2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-I0781
    Boc-Hyp-OH 13726-69-7 99.78%
    Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2]
    Boc-Hyp-OH
  • HY-141165
    TCO-NHS ester 1191901-33-3
    TCO-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
    TCO-NHS ester
  • HY-140128
    DBCO-S-S-PEG3-biotin 1430408-09-5
    DBCO-S-S-PEG3-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-S-S-PEG3-biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-S-S-PEG3-biotin
  • HY-128833
    Bis-NH2-PEG2 929-59-9 99.49%
    Bis-NH2-PEG2 (PROTAC Linker 19) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Bis-NH2-PEG2
  • HY-140150
    Azido-PEG3-Val-Cit-PAB-PNP 2055047-18-0 99.09%
    Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG3-Val-Cit-PAB-PNP is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-Val-Cit-PAB-PNP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-Val-Cit-PAB-PNP
  • HY-140087
    N-(Amino-PEG2)-N-bis(PEG3-azide) 2606952-86-5 ≥98.0%
    N-(Amino-PEG2)-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Amino-PEG2)-N-bis(PEG3-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Amino-PEG2)-N-bis(PEG3-azide)
  • HY-138382
    m-PEG4-PFP ester 2952895-31-5 ≥98.0%
    m-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG4-PFP ester
  • HY-W007341
    Pentaethylene glycol 4792-15-8 98.42%
    Pentaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Pentaethylene glycol
  • HY-W010975
    Fmoc-Lys-OH hydrochloride 139262-23-0 99.48%
    Fmoc-Lys-OH hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys-OH hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-Lys-OH hydrochloride
  • HY-138470
    Azido-PEG2-C6-Cl 2568146-55-2
    Azido-PEG2-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C6-Cl is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-C6-Cl
  • HY-140814
    Azido-PEG4-hydrazide 2170240-96-5 99.62%
    Azido-PEG4-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-hydrazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-hydrazide
  • HY-113697
    Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD 1037589-69-7 99.77%
    Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD (Mal-PEG2-AZD) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD
  • HY-120537
    m-PEG5-CH2COOH 16142-03-3 99.00%
    m-PEG5-CH2COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG5-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG5-CH2COOH
  • HY-140009
    Azido-PEG1-C2-acid 1393330-34-1 ≥98.0%
    Azido-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-C2-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG1-C2-acid
  • HY-114670
    Propargyl-PEG4-amine 1013921-36-2 99.71%
    Propargyl-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-amine
  • HY-141269
    Methyltetrazine-PEG5-NHS ester 1802907-92-1
    Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyltetrazine-PEG5-NHS ester
  • HY-130659
    Amino-PEG8-amine 82209-36-7 ≥98.0%
    Amino-PEG8-amine is a PEG-based (8 units) PROTAC linker can be used in the synthesis of PROTACs.
    Amino-PEG8-amine
  • HY-W013458
    Bis(2-bromoethyl) ether 5414-19-7 99.91%
    Bis2-bromoethyl ether is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis(2-bromoethyl) ether
  • HY-40141
    1-Boc-azetidine-3-carboxylic acid 142253-55-2 ≥98.0%
    1-Boc-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2]
    1-Boc-azetidine-3-carboxylic acid
  • HY-135911
    Biotin-PEG2-OH 717119-80-7 ≥98.0%
    Biotin-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG2-OH
PROTAC Linkers Isoform Comparison

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